Ochratoxin A–Mediated DNA and Protein Damage: Roles of Nitrosative and Oxidative Stresses

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...

Lycopene prevents experimental priapism against oxidative and nitrosative damage.

OBJECTIVE Priapism is a persistent and often painful penile erection in the absence of sexual stimulation. It can cause progressive fibrosis, edema and drying of the erectile tissue and then it can lead to erectile dysfunction. Previous studies suggested that, neuronal nitric oxide levels increased during the priapism. High NO levels can result in the formation of reactive oxygen species (ROS) ...

The effect of pumpkin seed and endurance training on oxidative stress factors and DNA damage

Objective: This study aimed to investigate the effect of pumpkin seed and endurance training on oxidative stress factors and DNA damage of slow-twitch muscle tissue in male rats poisoned with hydrogen peroxide. Materials and Methods: A total of 48 adult male rats weighing 220±20 g at eight weeks were administered in accordance with stress interventions (hydrogen peroxide), pumpkin seed and end...

Severity of Oxidative DNA Damage in Gastric Tissue of Smoker and Non-smoker Patients

Spring summer 2010, Vol.4, No.1 /74 Medical Laboratory Journal Severity of Oxidative DNA Damage in Gastric Tissue of Smoker and Non-smoker Patients with Dyspepsia Abstract Background and Objectives: Cigarette smoking is associated with an increase in risk of peptic ulcer and Gastro-Intestinal cancer. Toxic materials in smoke and tar have a significant role in production of carcinogenic complexe...

Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds